Endocrine Abstracts

Background: Diabetic autonomic neuropathy (DAN) is among the least recognized and understood complication of diabetes despite its significant negative impact on survival and quality of life in people with diabetes. Diabetic neuropathies including cardiac autonomic neuropathy (CAN), are a common chronic complication of type 1 and Type 2 diabetes and confer a high morbidity and mortality to diabetic pateints. The reported prevalence of CAN varies greatly depending on the criteri...

Metabolic Syndrome (Met S), is associated with increased risk of cardiovascular disease (CVD) and mortality, the presence of 1 or 2 components of the (MetS) increases overall mortality compared with the absence of any component of the (MetS). Epidemiological studies have shown that low testosterone is associated with MetS. While testosterone levels decline with age, Estradiol (E2) levels remain relatively stable resulting in a decreased testosterone: E2 ratio (T:E), Whether th...

Type 1 diabetes mellitus (DM) is a multi system disease with both biochemical and anatomic/structural consequences. A number of components of the metabolic syndrome may be observed in patients with type 1 diabetes. It was suggested that treating obese adolescents with insulin resistance using metformin is an option for patients without response to traditional lifestyle change. It was reported that fetuin-A could inhibit insulin receptor tyrosine kinase activity and induced a l...

Background: Diabetic retinopathy (DR) is a clinically well-defined sight-threatening complication in type 2 diabetes. Angiopoietin 1 (Ang1) has been shown to promote endothelial cell survival without causing proliferation, stabilise endothelial interactions with surrounding support cells and can block the vascular permeability effects of vascular endothelial growth factor (VEGF). More recent data suggest that balance between these growth factors may affect vascular endothelial...